Human AZIN1 protein (Recombinant) (N-His) (STJP003212)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AZIN1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AZIN1 |
| Gene ID | 51582 |
| Uniprot ID | AZIN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile5-Lys290 |
Additional Info
| Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizyme OAZ1. |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. |
| Protein Name | Antizyme Inhibitor 1AziAzi1Ornithine Decarboxylase Antizyme Inhibitor |
| Database Links | Reactome: R-HSA-350562 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Antizyme Inhibitor 1 proteinAzi proteinAzi1 proteinOrnithine Decarboxylase Antizyme Inhibitor proteinAZIN1 proteinOAZI proteinOAZIN protein |
Information sourced from Uniprot.org