Human AURKC protein (Recombinant) (N-His) (STJP006223)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AURKC-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AURKC |
| Gene ID | 6795 |
| Uniprot ID | AURKC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu20-Gln277 |
Additional Info
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Protein Names | Aurora Kinase C proteinAurora 3 proteinAurora/Ipl1-Related Kinase 3 proteinArk-3 proteinAurora-Related Kinase 3 proteinAurora/Ipl1/Eg2 Protein 2 proteinSerine/Threonine-Protein Kinase 13 proteinSerine/Threonine-Protein Kinase Aurora-C proteinAURKC proteinAIE2 proteinAIK3 proteinAIRK3 proteinARK3 proteinSTK13 protein |
Information sourced from Uniprot.org