Human ATP6V1A protein (Recombinant) (N-His) (STJP007419)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP6V1A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATP6V1A |
| Gene ID | 523 |
| Uniprot ID | VATA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys456-Asp617 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity. |
| Function | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. |
| Protein Name | V-Type Proton Atpase Catalytic Subunit AV-Atpase Subunit AV-Atpase 69 Kda SubunitVacuolar Atpase Isoform Va68Vacuolar Proton Pump Subunit Alpha |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712Reactome: R-HSA-9857377 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesicleSecretory VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinLysosomeCo-Localizes With Wfs1 In The Secretory Granules In Neuroblastoma Cell Lines |
| Alternative Protein Names | V-Type Proton Atpase Catalytic Subunit A proteinV-Atpase Subunit A proteinV-Atpase 69 Kda Subunit proteinVacuolar Atpase Isoform Va68 proteinVacuolar Proton Pump Subunit Alpha proteinATP6V1A proteinATP6A1 proteinATP6V1A1 proteinVPP2 protein |
Information sourced from Uniprot.org