Human ATP6V0D1 protein (Recombinant) (N-His) (STJP007661)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP6V0D1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATP6V0D1 |
| Gene ID | 9114 |
| Uniprot ID | VA0D1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Phe351 |
Additional Info
| Function | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. |
| Protein Name | V-Type Proton Atpase Subunit D 1V-Atpase Subunit D 132 Kda Accessory ProteinV-Atpase 40 Kda Accessory ProteinV-Atpase Ac39 SubunitP39Vacuolar Proton Pump Subunit D 1 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-381038Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712Reactome: R-HSA-9857377 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmic SideLysosome MembraneCytoplasmic VesicleClathrin-Coated Vesicle MembraneLocalizes To Centrosome And The Base Of The Cilium |
| Alternative Protein Names | V-Type Proton Atpase Subunit D 1 proteinV-Atpase Subunit D 1 protein32 Kda Accessory Protein proteinV-Atpase 40 Kda Accessory Protein proteinV-Atpase Ac39 Subunit proteinP39 proteinVacuolar Proton Pump Subunit D 1 proteinATP6V0D1 proteinATP6D proteinVPATPD protein |
Information sourced from Uniprot.org