Human ATP1B1 protein (Recombinant) (N-His) (STJP007707)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP1B1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATP1B1 |
| Gene ID | 481 |
| Uniprot ID | AT1B1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly76-Ser303 |
Additional Info
| Post Translational Modifications | Glutathionylated. N-glycosylated. |
| Function | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1. Involved in cell adhesion and establishing epithelial cell polarity. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Beta-1Sodium/Potassium-Dependent Atpase Subunit Beta-1 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSarcolemmaColocalizes With Obscn At The Intercalated Disk And Sarcolemma In CardiomyocytesLocalizes In Long Striations At The Level Of Z And M Lines |
| Alternative Protein Names | Sodium/Potassium-Transporting Atpase Subunit Beta-1 proteinSodium/Potassium-Dependent Atpase Subunit Beta-1 proteinATP1B1 proteinATP1B protein |
Information sourced from Uniprot.org