Human ATG13 protein (Recombinant) (N-His) (STJP009583)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATG13-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATG13 |
| Gene ID | 9776 |
| Uniprot ID | ATG13_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp57-Arg190 |
Additional Info
| Function | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. |
| Protein Name | Autophagy-Related Protein 13 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | CytoplasmCytosolPreautophagosomal StructureUnder Starvation ConditionsIs Localized To Puncate Structures Primarily Representing The Isolation MembraneThe Isolation Membrane Sequesters A Portion Of The Cytoplasm Resulting In Autophagosome Formation |
| Alternative Protein Names | Autophagy-Related Protein 13 proteinATG13 proteinKIAA0652 protein |
Information sourced from Uniprot.org