Human ATF1 protein (Recombinant) (His-Tag) (STJP017497)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ATF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 50% Glycerol, 0.2M NaCl, 2mM EDTA |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATF1 |
| Gene ID | 466 |
| Uniprot ID | ATF1_HUMAN |
| Accession Number | NP_005162.1 |
| Immunogen | Human |
| Immunogen Region | 1-271aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. |
| Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGTACAG-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-1Camp-Dependent Transcription Factor Atf-1Activating Transcription Factor 1Protein Treb36 |
| Database Links | Reactome: R-HSA-199920Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Cyclic Amp-Dependent Transcription Factor Atf-1 proteinCamp-Dependent Transcription Factor Atf-1 proteinActivating Transcription Factor 1 proteinProtein Treb36 proteinATF1 protein |
Information sourced from Uniprot.org