Human ATAT1 protein (Recombinant) (N-His) (STJP005556)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATAT1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATAT1 |
| Gene ID | 79969 |
| Uniprot ID | ATAT_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Pro196 |
Additional Info
| Function | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics.this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
| Protein Name | Alpha-Tubulin N-Acetyltransferase 1Alpha-TatAlpha-Tat1TatAcetyltransferase Mec-17 Homolog |
| Database Links | Reactome: R-HSA-5617833 |
| Cellular Localisation | CytoplasmMembraneClathrin-Coated PitCell JunctionFocal AdhesionCell ProjectionAxonCytoskeletonSpindle |
| Alternative Protein Names | Alpha-Tubulin N-Acetyltransferase 1 proteinAlpha-Tat proteinAlpha-Tat1 proteinTat proteinAcetyltransferase Mec-17 Homolog proteinATAT1 proteinC6orf134 proteinMEC17 proteinNbla00487 protein |
Information sourced from Uniprot.org