Human ASRGL1 protein (Recombinant) (His-Tag) (STJP018979)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ASRGL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASRGL1 |
| Gene ID | 80150 |
| Uniprot ID | ASGL1_HUMAN |
| Accession Number | NP_001077395 |
| Immunogen | Human |
| Immunogen Region | 1-308aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMNPIVVV HGGGAGPISK DRKERVHQGM VRAATVGYGI LREGGSAVDA VEGAVVALED DPEFNAGCGS VLNTNGEVEM DASIMDGKDL SAGAVSAVQC IANPIKLARL VMEKTPHCFL TDQGAAQFAA AMGVPEIPGE KLVTERNKKR LEKEKHEKGA QKTDCQKNLG TVGAVALDCK GNVAYATSTG GIVNKMVGRV GDSPCLGA |
Additional Info
| Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. |
| Post Translational Modifications | Cleaved into an alpha and beta chain by autocatalysis.this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. |
| Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. |
| Protein Name | Isoaspartyl Peptidase/L-AsparaginaseAsparaginase-Like Protein 1Beta-Aspartyl-PeptidaseIsoaspartyl DipeptidaseL-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | CytoplasmMidpiece Of Sperm Tail |
| Alternative Protein Names | Isoaspartyl Peptidase/L-Asparaginase proteinAsparaginase-Like Protein 1 proteinBeta-Aspartyl-Peptidase proteinIsoaspartyl Dipeptidase proteinL-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain proteinASRGL1 proteinALP proteinCRASH protein |
Information sourced from Uniprot.org