Human ASPH protein (Recombinant) (His-Tag) (STJP016625)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ASPH-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASPH |
| Gene ID | 444 |
| Uniprot ID | ASPH_HUMAN |
| Accession Number | NP_001158227.1 |
| Immunogen | Human |
| Immunogen Region | 75-270aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level). |
| Function | Isoform 1: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Isoform 8: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. |
| Protein Name | Aspartyl/Asparaginyl Beta-HydroxylaseAspartate Beta-HydroxylaseAsp Beta-HydroxylasePeptide-Aspartate Beta-Dioxygenase |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775Reactome: R-HSA-9629569 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinIsoform 4: Sarcoplasmic Reticulum MembraneIsoform 8: Endoplasmic Reticulum Membrane |
| Alternative Protein Names | Aspartyl/Asparaginyl Beta-Hydroxylase proteinAspartate Beta-Hydroxylase proteinAsp Beta-Hydroxylase proteinPeptide-Aspartate Beta-Dioxygenase proteinASPH proteinBAH protein |
Information sourced from Uniprot.org