Human ASIC2 protein (Recombinant) (N-His) (STJP008176)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ASIC2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ASIC2 |
| Gene ID | 40 |
| Uniprot ID | ASIC2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln71-Lys421 |
Additional Info
| Function | Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system. Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize. Highly selective for sodium, they are permeable to other cations. By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction. |
| Protein Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Protein Names | Acid-Sensing Ion Channel 2 proteinAsic2 proteinAmiloride-Sensitive Cation Channel 1 - Neuronal proteinAmiloride-Sensitive Cation Channel Neuronal 1 proteinBrain Sodium Channel 1 proteinBnc1 proteinBnac1 proteinMammalian Degenerin Homolog proteinMdeg proteinASIC2 proteinACCN proteinACCN1 protein |
Information sourced from Uniprot.org