Human ARL2 protein (Recombinant) (N-His) (STJP008100)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ARL2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ARL2 |
| Gene ID | 402 |
| Uniprot ID | ARL2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp184 |
Additional Info
| Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Also regulates mitochondrial integrity and function. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 2 |
| Database Links | Reactome: R-HSA-389977Reactome: R-HSA-83936Reactome: R-HSA-9648002 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusThe Complex Formed With Arl2bpArl2 And Slc25a6 Is Expressed In MitochondriaArl2 And Slc25a4 Is Expressed In MitochondriaNot Detected In The GolgiNucleus And On The Mitotic SpindleCentrosome-Associated Throughout The Cell CycleNot Detected To Interphase Microtubules |
| Alternative Protein Names | Adp-Ribosylation Factor-Like Protein 2 proteinARL2 protein |
Information sourced from Uniprot.org