Human ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) Sandwich ELISA Kit (STJE0007308)

Human ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) Sandwich ELISA Kit (STJE0007308)

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STJE0007308
£421.50 - £586.50
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 29.4pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description : This ARHGEF7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: ARHGEF7
Gene ID: 8874
Uniprot ID: ARHG7_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1.
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Protein Name Rho Guanine Nucleotide Exchange Factor 7
Beta-Pix
Cool-1
Pak-Interacting Exchange Factor Beta
P85
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-193648
Reactome: R-HSA-3928664
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9619229 Q14155-1
Cellular Localisation Cell Junction
Focal Adhesion
Cell Projection
Ruffle
Cytoplasm
Cell Cortex
Lamellipodium
Detected At Cell Adhesions
A Small Proportion Is Detected At Focal Adhesions
Alternative ELISA Names Rho Guanine Nucleotide Exchange Factor 7 ELISA kit
Beta-Pix ELISA kit
Cool-1 ELISA kit
Pak-Interacting Exchange Factor Beta ELISA kit
P85 ELISA kit
ARHGEF7 ELISA kit
COOL1 ELISA kit
KIAA0142 ELISA kit
P85SPR ELISA kit
PAK3BP ELISA kit
PIXB ELISA kit
Nbla10314 ELISA kit
output

Information sourced from Uniprot.org

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