Human ARHGEF25 protein (Recombinant) (N-His) (STJP007565)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ARHGEF25-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ARHGEF25 |
| Gene ID | 115557 |
| Uniprot ID | ARHGP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser149-Ser490 |
Additional Info
| Function | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 25Guanine Nucleotide Exchange Factor GeftRac/Cdc42/Rho Exchange Factor GeftRhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor GeftP63rhogef |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell MembraneCytoplasmMyofibrilSarcomereHighly Colocalizes With Actin Regions |
| Alternative Protein Names | Rho Guanine Nucleotide Exchange Factor 25 proteinGuanine Nucleotide Exchange Factor Geft proteinRac/Cdc42/Rho Exchange Factor Geft proteinRhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor Geft proteinP63rhogef proteinARHGEF25 proteinGEFT protein |
Information sourced from Uniprot.org