Human ARHGEF15 protein (Recombinant) (N-His) (STJP016355)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ARHGEF15-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ARHGEF15 |
| Gene ID | 22899 |
| Uniprot ID | ARHGF_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg619-Thr741 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination. Ubiquitinated.UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. |
| Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 15Ephexin-5E5Vsm-Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell ProjectionDendriteExpressed Exclusively In Dendrites Of The Developing Hippocampus |
| Alternative Protein Names | Rho Guanine Nucleotide Exchange Factor 15 proteinEphexin-5 proteinE5 proteinVsm-Rhogef proteinARHGEF15 proteinKIAA0915 protein |
Information sourced from Uniprot.org