Human ARHGEF12 protein (Recombinant) (N-His) (STJP015196)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ARHGEF12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ARHGEF12 |
| Gene ID | 23365 |
| Uniprot ID | ARHGC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn366-Gly556 |
Additional Info
| Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 12Leukemia-Associated Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-416572Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148 |
| Cellular Localisation | CytoplasmMembraneTranslocated To The Membrane Upon Stimulation |
| Alternative Protein Names | Rho Guanine Nucleotide Exchange Factor 12 proteinLeukemia-Associated Rhogef proteinARHGEF12 proteinKIAA0382 proteinLARG protein |
Information sourced from Uniprot.org