Human ARFIP2 protein (Recombinant) (His-Tag) (STJP017804)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ARFIP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARFIP2 |
| Gene ID | 23647 |
| Uniprot ID | ARFP2_HUMAN |
| Accession Number | NP_036534 |
| Immunogen | Human |
| Immunogen Region | 1-341aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTDGILG KAATMEIPIH GNGEARQLPE DDGLEQDLQQ VMVSGPNLNE TSIVSGGYGG SGDGLIPTGS GRHPSHSTTP SGPGDEVARG IAGEKFDIVK KWGINTYKCT KQLLSERFGR GSRTVDLELE LQIELLRETK RKYESVLQLG RALTAHLYSL LQTQHALGDA FADLSQKSPE LQEEFGYNAE TQKLLCKNGE TLLGAVNF |
Additional Info
| Function | Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. |
| Protein Name | Arfaptin-2Adp-Ribosylation Factor-Interacting Protein 2Partner Of Rac1Por1 |
| Database Links | Reactome: R-HSA-6811440 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network Membrane |
| Alternative Protein Names | Arfaptin-2 proteinAdp-Ribosylation Factor-Interacting Protein 2 proteinPartner Of Rac1 proteinPor1 proteinARFIP2 proteinPOR1 protein |
Information sourced from Uniprot.org