Human Apolipoprotein C1/APOC1 protein (Recombinant) (His-Tag) (STJP018653)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Apolipoprotein C1/APOC1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOC1 |
| Gene ID | 341 |
| Uniprot ID | APOC1_HUMAN |
| Accession Number | NP_001636.1 |
| Immunogen | Human |
| Immunogen Region | 27-83aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. |
| Function | Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. |
| Protein Name | Apolipoprotein C-IApo-CiApoc-IApolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I |
| Database Links | Reactome: R-HSA-8866423Reactome: R-HSA-8964046Reactome: R-HSA-9029569 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Apolipoprotein C-I proteinApo-Ci proteinApoc-I proteinApolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I proteinAPOC1 protein |
Information sourced from Uniprot.org