Human APLP1 protein (Recombinant) (C-His) (STJP013361)

Name: Human APLP1 protein (Recombinant) (C-His) (STJP013361)
SKU: STJP013361-100
Price: 454.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013361-100

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Short Description	Recombinant-Human APLP1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a 0.22 Mu m filtered solution in PBS, 1mM EDTA, pH 7.4.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Post Translational Modifications	Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Function	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Protein Name	Amyloid Beta Precursor Like Protein 1 Amyloid Beta A4 Precursor-Like Protein 1 Amyloid-Like Protein 1 Aplp Aplp-1 Cleaved Into - C30
Database Links
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein C30: Cytoplasm C-Terminally Processed In The Golgi Complex
Alternative Protein Names	Amyloid Beta Precursor Like Protein 1 protein Amyloid Beta protein A4 Precursor-Like Protein 1 protein Amyloid-Like Protein 1 protein Aplp protein Aplp-1 Cleaved Into - C30 protein APLP1 protein

Information sourced from Uniprot.org