Human APLP-1 protein (Recombinant) (C-His) (STJP001344)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human APLP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser39-Glu580) of human APLP1 (Accession #NP_005157.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human APLP-1-C-His protein was developed in hek293 cells using the region Ser39-Glu580. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | APLP1 |
| Gene ID | 333 |
| Uniprot ID | APLP1_HUMAN |
| Immunogen | Recombinant Human APLP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser39-Glu580) of human APLP1 (Accession #NP_005157.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Ser39-Glu580 |
| Immunogen Sequence | SLAGGSPGAAEAPGSAQVAG LCGRLTLHRDLRTGRWEPDP QRSRRCLRDPQRVLEYCRQM YPELQIARVEQATQAIPMER WCGGSRSGSCAHPHHQVVPF RCLPGEFVSEALLVPEGCRF LHQERMDQCESSTRRHQEAQ EACSSQGLILHGSGMLLPCG SDRFRGVEYVCCPPPGTPDP SGTAVGDPSTRSWPPGSRVE GAEDEEEEESFPQPVDDYFV EPPQAEEEEETVPPPSSHT |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1Amyloid BetaA4 Precursor-Like Protein 1Amyloid-Like Protein 1AplpAplp-1 Cleaved Into - C30 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinC30: CytoplasmC-Terminally Processed In The Golgi Complex |
| Alternative Protein Names | Amyloid Beta Precursor Like Protein 1 proteinAmyloid Beta proteinA4 Precursor-Like Protein 1 proteinAmyloid-Like Protein 1 proteinAplp proteinAplp-1 Cleaved Into - C30 proteinAPLP1 protein |
Information sourced from Uniprot.org