Human APIP protein (Recombinant) (His-Tag) (STJP017723)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human APIP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APIP |
| Gene ID | 51074 |
| Uniprot ID | MTNB_HUMAN |
| Accession Number | NP_057041 |
| Immunogen | Human |
| Immunogen Region | 1-242aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMSGCDA REGDCCSRRC GAQDKEHPRY LIPELCKQFY HLGWVTGTGG GISLKHGDEI YIAPSGVQKE RIQPEDMFVC DINEKDISGP SPSKKLKKSQ CTPLFMNAYT MRGAGAVIHT HSKAAVMATL LFPGREFKIT HQEMIKGIKK CTSGGYYRYD DMLVVPIIEN TPEEKDLKDR MAHAMNEYPD SCAVLVRRHG VYVWGETW |
Additional Info
| Tissue Specificity | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. |
| Function | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. |
| Protein Name | Methylthioribulose-1-Phosphate DehydrataseMtru-1-P DehydrataseApaf1-Interacting ProteinHapip |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-1237112Reactome: R-HSA-9627069 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Methylthioribulose-1-Phosphate Dehydratase proteinMtru-1-P Dehydratase proteinApaf1-Interacting Protein proteinHapip proteinAPIP proteinCGI-29 protein |
Information sourced from Uniprot.org