Human APAF1 protein (Recombinant) (N-His) (STJP003192)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human APAF1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | APAF1 |
| Gene ID | 317 |
| Uniprot ID | APAF_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser31-Phe350 |
Additional Info
| Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. |
| Protein Name | Apoptotic Protease-Activating Factor 1Apaf-1 |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-111459Reactome: R-HSA-111463Reactome: R-HSA-111464Reactome: R-HSA-6798695Reactome: R-HSA-6803207Reactome: R-HSA-8953750Reactome: R-HSA-9627069 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Apoptotic Protease-Activating Factor 1 proteinApaf-1 proteinAPAF1 proteinKIAA0413 protein |
Information sourced from Uniprot.org