Human AP3B1 protein (Recombinant) (N-His) (STJP003131)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AP3B1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AP3B1 |
| Gene ID | 8546 |
| Uniprot ID | AP3B1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Leu233 |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues. Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) impairs interaction with KIF3A. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue. |
| Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Protein Name | Ap-3 Complex Subunit Beta-1Adaptor Protein Complex Ap-3 Subunit Beta-1Adaptor-Related Protein Complex 3 Subunit Beta-1Beta-3a-AdaptinClathrin Assembly Protein Complex 3 Beta-1 Large Chain |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6802952 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusComponent Of The Coat Surrounding The Cytoplasmic Face Of Coated Vesicles Located At The Golgi Complex |
| Alternative Protein Names | Ap-3 Complex Subunit Beta-1 proteinAdaptor Protein Complex Ap-3 Subunit Beta-1 proteinAdaptor-Related Protein Complex 3 Subunit Beta-1 proteinBeta-3a-Adaptin proteinClathrin Assembly Protein Complex 3 Beta-1 Large Chain proteinAP3B1 proteinADTB3A protein |
Information sourced from Uniprot.org