Human AP1AR protein (Recombinant) (His-Tag) (STJP018424)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AP1AR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AP1AR |
| Gene ID | 55435 |
| Uniprot ID | AP1AR_HUMAN |
| Accession Number | NP_061039 |
| Immunogen | Human |
| Immunogen Region | 1-302aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGNCCWTQCF GLLRKEAGRL QRVGGGGGSK YFRTCSRGEH LTIEFENLVE SDEGESPGSS HRPLTEEEIV DLRERHYDSI AEKQKDLDKK IQKELALQEE KLRLEEEALY AAQREAARAA KQRKLLEQER QRIVQQYHPS NNGEYQSSGP EDDFESCLRN MKSQYEVFRS SRLSSDATVL TPNTESSCDL MTKTKSTSGN DDSTSLDL |
Additional Info
| Post Translational Modifications | Palmitoylated. |
| Function | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function.negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. |
| Protein Name | Ap-1 Complex-Associated Regulatory Protein2c18Adaptor-Related Protein Complex 1-Associated Regulatory ProteinGamma-1-Adaptin Brefeldin A Resistance ProteinGbarGamma-BarGamma-A1-Adaptin And Kinesin InteractorGadkin |
| Database Links | |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkLate EndosomeEarly EndosomeLocalizes To The Juxta-Nuclear Golgi Region And To Tubular Structures Throughout The CytoplasmWhich Are Highly Mobile And Cycle Between The Juxta-Nuclear Area And The Cell Periphery |
| Alternative Protein Names | Ap-1 Complex-Associated Regulatory Protein protein2c18 proteinAdaptor-Related Protein Complex 1-Associated Regulatory Protein proteinGamma-1-Adaptin Brefeldin A Resistance Protein proteinGbar proteinGamma-Bar proteinGamma-A1-Adaptin And Kinesin Interactor proteinGadkin proteinAP1AR proteinC4orf16 proteinPRO0971 protein |
Information sourced from Uniprot.org