Human AMSH-LP protein (Recombinant) (His-Tag) (STJP018062)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AMSH-LP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% Glycerol, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAMBPL1 |
| Gene ID | 57559 |
| Uniprot ID | STALP_HUMAN |
| Accession Number | NP_065850 |
| Immunogen | Human |
| Immunogen Region | 1-436aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains. |
| Protein Name | Amsh-Like ProteaseAmsh-LpStam-Binding Protein-Like 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | |
| Alternative Protein Names | Amsh-Like Protease proteinAmsh-Lp proteinStam-Binding Protein-Like 1 proteinSTAMBPL1 proteinAMSHLP proteinKIAA1373 protein |
Information sourced from Uniprot.org