Human AMH (Muellerian-Inhibiting Factor) Sandwich ELISA Kit (STJE0000005)
SPECIFICATIONS
ConjugationBiotin
General Information
| Short Description | This Muellerian-Inhibiting Factor Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma and cell culture supernates. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 40.5 pg/mL |
| Detection Limit | 156-10000 pg/ml |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Storage Instruction | Unopened kits can be stored at 2-8Β°C for 1 year, and opened products must be used within 1 month. |
| Assay Time | 4 hours |
| Detection | Colorimetric |
Target Information
| Gene Symbol | AMH |
| Gene ID | 268 |
| Uniprot ID | MIS_HUMAN |
| Sample Type | serum, plasma and cell culture supernates |
Additional Info
| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Muellerian-Inhibiting Factor ELISA kitAnti-Muellerian Hormone ELISA kitAmh ELISA kitMuellerian-Inhibiting Substance ELISA kitMis ELISA kitAMH ELISA kitMIF ELISA kit |
| output |
Information sourced from Uniprot.org