Human AMH (Muellerian-Inhibiting Factor) Antibody Pair (STJAP00371)
General Information
| Short Description | This AMH antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | AMH |
| Gene ID | 268 |
| Uniprot ID | MIS_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human AMH protien.Detection Immunogen: Recombinant Human AMH protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Muellerian-Inhibiting Factor antibody pairAnti-Muellerian Hormone antibody pairAmh antibody pairMuellerian-Inhibiting Substance antibody pairMis antibody pairAMH antibody pairMIF antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human AMH (Muellerian-Inhibiting Factor) Antibody Pair (STJAP00371)
This antibody pair detects human AMH (Anti-Mullerian Hormone, also known as Muellerian-Inhibiting Factor), corresponding to UniProt entry P03971. Reactivity is confirmed for human samples only.
Both antibodies are mouse-derived and purified by Protein A or G. The capture antibody is unconjugated, supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5, while the detection antibody is biotinylated and supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
This antibody pair has been validated for use in ELISA. Both antibodies were raised against recombinant human AMH protein and are intended for sandwich ELISA development using serum, plasma, and other biological fluids.
The antibody pair is suitable for use with human serum, plasma, and other biological fluids. This product is for research use only and is not validated for diagnostic or therapeutic applications.
Both components should be stored at -20°C for long-term storage. Repeated freeze-thaw cycles should be avoided, so aliquoting upon receipt is advisable.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.