• Human AMH (AMH) Sandwich ELISA Kit (STJE0000005)

Human AMH (AMH) Sandwich ELISA Kit (STJE0000005)

SKU:
STJE0000005-96

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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 40.5 pg/mL
Detection Limit: 156-10000 pg/ml
Short Description: This AMH Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: AMH
Gene ID: 268
Uniprot ID: MIS_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity In ovaries, AMH is detected in granulosa cells of early growing follicles.
Post Translational Modifications Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
Function Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Protein Name Muellerian-Inhibiting Factor
Anti-Muellerian Hormone
Amh
Muellerian-Inhibiting Substance
Mis
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-9690406
Cellular Localisation Secreted
Alternative ELISA Names Muellerian-Inhibiting Factor ELISA kit
Anti-Muellerian Hormone ELISA kit
Amh ELISA kit
Muellerian-Inhibiting Substance ELISA kit
Mis ELISA kit
AMH ELISA kit
MIF ELISA kit
output

Information sourced from Uniprot.org

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