Human AMER1 protein (Recombinant) (N-GST & C-His) (STJP015898)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AMER1-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | AMER1 |
| Gene ID | 139285 |
| Uniprot ID | AMER1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly552-Pro650 |
Additional Info
| Function | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. |
| Protein Name | Apc Membrane Recruitment Protein 1Amer1Protein Fam123bWilms Tumor Gene On The X Chromosome Protein |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusShuttles Between Nucleus And CytoplasmDetected In Nuclear Paraspeckles That Are Found Close To Splicing SpecklesTranslocates To The Cell Membrane Following Binding To Ptdins(45)P2 |
| Alternative Protein Names | Apc Membrane Recruitment Protein 1 proteinAmer1 proteinProtein Fam123b proteinWilms Tumor Gene On The X Chromosome Protein proteinAMER1 proteinFAM123B proteinWTX protein |
Information sourced from Uniprot.org