Human ALOX12B protein (Recombinant) (N-His) (STJP003350)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ALOX12B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ALOX12B |
| Gene ID | 242 |
| Uniprot ID | LX12B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu479-Ile701 |
Additional Info
| Function | Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins. |
| Protein Name | Arachidonate 12-Lipoxygenase - 12r-Type12r-Lox12r-LipoxygenaseEpidermis-Type Lipoxygenase 12 |
| Database Links | Reactome: R-HSA-2142712 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Protein Names | Arachidonate 12-Lipoxygenase - 12r-Type protein12r-Lox protein12r-Lipoxygenase proteinEpidermis-Type Lipoxygenase 12 proteinALOX12B protein |
Information sourced from Uniprot.org