Human ALKBH7 protein (Recombinant) (N-His) (STJP009044)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ALKBH7-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ALKBH7 |
| Gene ID | 84266 |
| Uniprot ID | ALKB7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser16-Cys221 |
Additional Info
| Function | May function as protein hydroxylase.can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - MitochondrialAlkylated Dna Repair Protein Alkb Homolog 7Spermatogenesis Cell Proliferation-Related ProteinSpermatogenesis-Associated Protein 11 |
| Database Links | |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - Mitochondrial proteinAlkylated Dna Repair Protein Alkb Homolog 7 proteinSpermatogenesis Cell Proliferation-Related Protein proteinSpermatogenesis-Associated Protein 11 proteinALKBH7 proteinABH7 proteinSPATA11 proteinUNQ6002 proteinPRO34564 protein |
Information sourced from Uniprot.org