| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
ACVR1C |
| Gene ID: |
130399 |
| Uniprot ID: |
ACV1C_HUMAN |
| Immunogen: |
Recombinant Human ALK-7/ACVR1C Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu22-Glu113) of human ALK-7 Protein (Accession #NP_660302.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: |
LSPGLKCVCLLCDSSNFTCQ TEGACWASVMLTNGKEQVIK SCVSLPELNAQVFCHSSNNV TKTECCFTDFCNNITLHLPT ASPNAPKLGPME |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
| Protein Name | Activin Receptor Type-1cActivin Receptor Type IcActr-IcActivin Receptor-Like Kinase 7Alk-7 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-1c proteinActivin Receptor Type Ic proteinActr-Ic proteinActivin Receptor-Like Kinase 7 proteinAlk-7 proteinACVR1C proteinALK7 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
