Human ACVR1/ALK-2 protein (Recombinant-Active) (C-hFc-His) (STJP012069)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human ACVR1/ALK-2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human BMP-6 is used at 0.25 Mu g/mL, the concentration of recombinant human ACVR1/ALK-2 that produces 50% of the optimal binding response is found to be approximately 1-5 Mu g/mL |
Target Information
| Gene Symbol | ACVR1 |
| Gene ID | 90 |
| Uniprot ID | ACVR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp23-Val124 |
Additional Info
| Function | Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. May promote the expression of HAMP, potentially via its interaction with BMP6. |
| Protein Name | Activin Receptor Type-1Activin Receptor Type IActr-IActivin Receptor-Like Kinase 2Alk-2Serine/Threonine-Protein Kinase Receptor R1Skr1Tgf-B Superfamily Receptor Type ITsr-I |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-1 proteinActivin Receptor Type I proteinActr-I proteinActivin Receptor-Like Kinase 2 proteinAlk-2 proteinSerine/Threonine-Protein Kinase Receptor R1 proteinSkr1 proteinTgf-B Superfamily Receptor Type I proteinTsr-I proteinACVR1 proteinACVRLK2 protein |
Information sourced from Uniprot.org