• Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)
  • Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)
  • Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)
  • Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)

Human ALK-1/ACVRL1 protein (Recombinant) (C-His) (STJP001078)

SKU:
STJP001078

£59.50 - £156.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human ALK-1/ACVRL1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Endotoxin: Please contact us for more information.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human ALK-1 at 4 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 0.08-2.4 Mu g/mL.
Gene Symbol: ACVRL1
Gene ID: 94
Uniprot ID: ACVL1_HUMAN
Immunogen: Recombinant Human ALK-1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp22-Gln118) of human ALK-1 (Accession #NP_000011.2) fused with a 6×His tag at the C-terminus.
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Protein Name Serine/Threonine-Protein Kinase Receptor R3
Skr3
Activin Receptor-Like Kinase 1
Alk-1
Tgf-B Superfamily Receptor Type I
Tsr-I
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Serine/Threonine-Protein Kinase Receptor R3 protein
Skr3 protein
Activin Receptor-Like Kinase 1 protein
Alk-1 protein
Tgf-B Superfamily Receptor Type I protein
Tsr-I protein
ACVRL1 protein
ACVRLK1 protein
ALK1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance