Human Aldo-keto reductase 7A3/AKR7A3 protein (Recombinant) (No-Tag) (STJP019262)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Aldo-keto reductase 7A3/AKR7A3-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 800pmol/min/ug, and is defined as the amount of enzyme that catalyze the reduction 1.0pmole of 1, 2-Naphthoquinone presence of NADPH per minute at pH 7.0 at 25C. |
Target Information
| Gene Symbol | AKR7A3 |
| Gene ID | 22977 |
| Uniprot ID | ARK73_HUMAN |
| Accession Number | AAH25709 |
| Immunogen | Human |
| Immunogen Region | 1-331aa |
| Immunogen Sequence | MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFVYS EGQSETILGG LGLRLGGSDC RVKIDTKAIP LFGNSLKPDS LRFQLETSLK RLQCPRVDLF YLHMPDHSTP VEETLRACHQ LHQEGKFVEL GLSNYAAWEV AEICTLCKSN GWILPTVYQG MYNAITRQVE TELFPCLRHF GLRFYAFNPL AGGLLTGKYK YEDKDGKQPV GRFFGNTW |
Additional Info
| Tissue Specificity | Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. |
| Function | Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity. |
| Protein Name | Aldo-Keto Reductase Family 7 Member A3Afb1 Aldehyde Reductase 2Afb1-Ar 2Aflatoxin B1 Aldehyde Reductase Member 3 |
| Database Links | Reactome: R-HSA-5423646 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Aldo-Keto Reductase Family 7 Member A3 proteinAfb1 Aldehyde Reductase 2 proteinAfb1-Ar 2 proteinAflatoxin B1 Aldehyde Reductase Member 3 proteinAKR7A3 proteinAFAR2 protein |
Information sourced from Uniprot.org