SDS-PAGE gel of recombinant human AKR7A3 protein stained with Coomassie blue

Human Aldo-keto reductase 7A3/AKR7A3 protein (Recombinant) (His-Tag) (STJP016617)

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STJP016617
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Short Description :Recombinant-Human Aldo-keto reductase 7A3/AKR7A3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity:Specific activity is > 700pmol/min/ug, and is defined as the amount of enzyme that catalyze the reduction 1.0pmole of 1, 2-Naphthoquinone presence of NADPH per minute at pH 7.0 at 25C.
Gene Symbol:AKR7A3
Gene ID:22977
Uniprot ID:ARK73_HUMAN
Accession Number:AAH25709.1
Immunogen:Human
Immunogen Region:1-331aa
Immunogen Sequence:M SRQLSRARPA TVLGAMEMGR RMDAPTSAAV TRAFLERGHT EIDTAFVYSE GQSETILGGL GLRLGGSDCR VKIDTKAIPL FGNSLKPDSL RFQLETSLKR LQCPRVDLFY LHMPDHSTPV EETLRACHQL HQEGKFVELG LSNYAAWEVA EICTLCKSNG WILPTVYQGM YNAITRQVET ELFPCL
Tissue Specificity Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Function Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity.
Protein Name Aldo-Keto Reductase Family 7 Member A3
Afb1 Aldehyde Reductase 2
Afb1-Ar 2
Aflatoxin B1 Aldehyde Reductase Member 3
Database Links Reactome: R-HSA-5423646
Cellular Localisation Cytoplasm
Alternative Protein Names Aldo-Keto Reductase Family 7 Member A3 protein
Afb1 Aldehyde Reductase 2 protein
Afb1-Ar 2 protein
Aflatoxin B1 Aldehyde Reductase Member 3 protein
AKR7A3 protein
AFAR2 protein

Information sourced from Uniprot.org

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