Human Aldo-keto reductase 1D1/AKR1D1 protein (Recombinant) (His-Tag) (STJP017090)

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STJP017090
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Aldo-keto reductase 1D1/AKR1D1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol, 100mM NaCl
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1D1
Gene ID: 6718
Uniprot ID: AK1D1_HUMAN
Immunogen Region: 1-326aa
Accession Number: NP_005980.1
Immunogen: Human
Immunogen Sequence: MDLSAASHRI PLSDGNSIPI IGLGTYSEPK STPKGACATS VKVAIDTGYR HIDGAYIYQN EHEVGEAIRE KIAEGKVRRE DIFYCGKLWA TNHVPEMVRP TLERTLRVLQ LDYVDLYIIE VPMAFKPGDE IYPRDENGKW LYHKSNLCAT WEAMEACKDA GLVKSLGVSN FNRRQLELIL NKPGLKHKPV SNQVECHPYF TQPKLL
Tissue Specificity Highly expressed in liver. Expressed in testis and weakly in colon.
Function Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).
Protein Name Aldo-Keto Reductase Family 1 Member D1
3-Oxo-5-Beta-Steroid 4-Dehydrogenase
Delta(4-3-Ketosteroid 5-Beta-Reductase
Delta(4-3-Oxosteroid 5-Beta-Reductase
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Cellular Localisation Cytoplasm
Alternative Protein Names Aldo-Keto Reductase Family 1 Member D1 protein
3-Oxo-5-Beta-Steroid 4-Dehydrogenase protein
Delta(4-3-Ketosteroid 5-Beta-Reductase protein
Delta(4-3-Oxosteroid 5-Beta-Reductase protein
AKR1D1 protein
SRD5B1 protein

Information sourced from Uniprot.org

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