Human Aldo-keto Reductase 1C1/AKR1C1 protein (Recombinant) (His-Tag) (STJP016637)

Name: Human Aldo-keto Reductase 1C1/AKR1C1 protein (Recombinant) (His-Tag) (STJP016637)
SKU: STJP016637
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP016637

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Short Description	Recombinant-Human Aldo-keto Reductase 1C1/AKR1C1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Enzyme Activity
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity	Specific activity is > 500pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25C.

Gene Symbol	AKR1C1
Gene ID	1645
Uniprot ID	AK1C1_HUMAN
Accession Number	NP_001344
Immunogen	Human
Immunogen Region	1-323aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKS

Tissue Specificity	Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Function	Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.
Protein Name	Aldo-Keto Reductase Family 1 Member C1 20-Alpha-Hydroxysteroid Dehydrogenase 20-Alpha-Hsd Chlordecone Reductase Homolog Hakrc Dihydrodiol Dehydrogenase 1 Dd1 High-Affinity Hepatic Bile Acid-Binding Protein Hbab
Database Links	Reactome: R-HSA-193368 Reactome: R-HSA-193775 Reactome: R-HSA-193807 Reactome: R-HSA-975634 Reactome: R-HSA-9757110
Cellular Localisation	Cytoplasm Cytosol
Alternative Protein Names	Aldo-Keto Reductase Family 1 Member C1 protein 20-Alpha-Hydroxysteroid Dehydrogenase protein 20-Alpha-Hsd protein Chlordecone Reductase Homolog Hakrc protein Dihydrodiol Dehydrogenase 1 protein Dd1 protein High-Affinity Hepatic Bile Acid-Binding Protein protein Hbab protein AKR1C1 protein DDH protein DDH1 protein

Information sourced from Uniprot.org