Human Aldehyde dehydrogenase 2/ALDH2 protein (Recombinant) (No-Tag) (STJP016415)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Aldehyde dehydrogenase 2/ALDH2-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 1mM EDTA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 250pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole Acetaldehyde by NAD per minute at pH 8.0 at 25 °C. |
Target Information
| Gene Symbol | ALDH2 |
| Gene ID | 217 |
| Uniprot ID | ALDH2_HUMAN |
| Accession Number | NP_000681.2 |
| Immunogen | Human |
| Immunogen Region | 18-517aa |
| Immunogen Sequence | MSAAATQAVP APNQQPEVFC NQIFINNEWH DAVSRKTFPT VNPSTGEVIC QVAEGDKEDV DKAVKAARAA FQLGSPWRRM DASHRGRLLN RLADLIERDR TYLAALETLD NGKPYVISYL VDLDMVLKCL RYYAGWADKY HGKTIPIDGD FFSYTRHEPV GVCGQIIPWN FPLLMQAWKL GPALATGNVV VMKVAEQTPL TALYVANLIK EAGFPPGVVN IVPGFGPT |
Additional Info
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Protein Name | Aldehyde Dehydrogenase - MitochondrialAldh Class 2Aldh-E2Aldhi |
| Database Links | Reactome: R-HSA-380612Reactome: R-HSA-445355Reactome: R-HSA-71384Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Aldehyde Dehydrogenase - Mitochondrial proteinAldh Class 2 proteinAldh-E2 proteinAldhi proteinALDH2 proteinALDM protein |
Information sourced from Uniprot.org