Human AKR7A2 protein (Recombinant) (N-His) (STJP010672)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AKR7A2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AKR7A2 |
| Gene ID | 8574 |
| Uniprot ID | ARK72_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg37-Asn356 |
Additional Info
| Function | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. |
| Protein Name | Aflatoxin B1 Aldehyde Reductase Member 2Afb1 Aldehyde Reductase 1Afb1-Ar 1Aldoketoreductase 7Succinic Semialdehyde ReductaseSsa Reductase |
| Database Links | Reactome: R-HSA-5423646 |
| Cellular Localisation | MitochondrionGolgi ApparatusCytoplasm |
| Alternative Protein Names | Aflatoxin B1 Aldehyde Reductase Member 2 proteinAfb1 Aldehyde Reductase 1 proteinAfb1-Ar 1 proteinAldoketoreductase 7 proteinSuccinic Semialdehyde Reductase proteinSsa Reductase proteinAKR7A2 proteinAFAR proteinAFAR1 proteinAKR7 protein |
Information sourced from Uniprot.org