Human AKR1C3 protein (Recombinant) (N-His) (STJP008204)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AKR1C3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AKR1C3 |
| Gene ID | 8644 |
| Uniprot ID | AK1C3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Tyr323 |
Additional Info
| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also displays retinaldehyde reductase activity toward 9-cis-retinal. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C3 17-Beta-Hydroxysteroid Dehydrogenase Type 517-Beta-Hsd 53-Alpha-Hsd Type Ii - Brain3-Alpha-Hydroxysteroid Dehydrogenase Type 23-Alpha-Hsd Type 2Chlordecone Reductase Homolog HakrbDihydrodiol Dehydrogenase 3Dd-3Dd3Dihydrodiol Dehydrogenase Type IHa1753Prostaglandin F SynthasePgfsTestosterone 17-Beta-Dehydrogenase 5 |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807Reactome: R-HSA-2162123Reactome: R-HSA-5365859Reactome: R-HSA-975634 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Aldo-Keto Reductase Family 1 Member C3 protein17-Beta-Hydroxysteroid Dehydrogenase Type 5 protein17-Beta-Hsd 5 protein3-Alpha-Hsd Type Ii - Brain protein3-Alpha-Hydroxysteroid Dehydrogenase Type 2 protein3-Alpha-Hsd Type 2 proteinChlordecone Reductase Homolog Hakrb proteinDihydrodiol Dehydrogenase 3 proteinDd-3 proteinDd3 proteinDihydrodiol Dehydrogenase Type I proteinHa1753 proteinProstaglandin F Synthase proteinPgfs proteinTestosterone 17-Beta-Dehydrogenase 5 proteinAKR1C3 proteinDDH1 proteinHSD17B5 proteinKIAA0119 proteinPGFS protein |
Information sourced from Uniprot.org