Human AIMP1 protein (Recombinant) (N-His) (STJP005268)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AIMP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AIMP1 |
| Gene ID | 9255 |
| Uniprot ID | AIMP1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys148-Lys312 |
Additional Info
| Function | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2Emap-2Endothelial Monocyte-Activating Polypeptide IiEmap-IiSmall Inducible Cytokine Subfamily E Member 1 |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | NucleusCytoplasmCytosolSecretedEndoplasmic ReticulumGolgi ApparatusEnriched In Secretory Vesicles Of Pancreatic Alpha Cells And Secreted From The Pancreas In Response To Low Glucose LevelsSecreted In Response To HypoxiaAlso Secreted In Response To Both Apoptotic And Necrotic Cell Death |
| Alternative Protein Names | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 proteinMultisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2 proteinEmap-2 proteinEndothelial Monocyte-Activating Polypeptide Ii proteinEmap-Ii proteinSmall Inducible Cytokine Subfamily E Member 1 proteinAIMP1 proteinEMAP2 proteinSCYE1 protein |
Information sourced from Uniprot.org