Human AIF-1/Iba1 protein (Recombinant) (His-Tag) (STJP017142)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AIF-1/Iba1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% Glycerol, 200mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AIF1 |
| Gene ID | 199 |
| Uniprot ID | AIF1_HUMAN |
| Accession Number | NP_001614 |
| Immunogen | Human |
| Immunogen Region | 1-147aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP |
Additional Info
| Tissue Specificity | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Protein Name | Allograft Inflammatory Factor 1Aif-1Ionized Calcium-Binding Adapter Molecule 1Protein G1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePhagocytic CupAssociated With The Actin Cytoskeleton At Membrane Ruffles And At Sites Of Phagocytosis |
| Alternative Protein Names | Allograft Inflammatory Factor 1 proteinAif-1 proteinIonized Calcium-Binding Adapter Molecule 1 proteinProtein G1 proteinAIF1 proteinG1 proteinIBA1 protein |
Information sourced from Uniprot.org