Human AICL/CLEC2B protein (Recombinant) (His-Tag) (STJP018009)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AICL/CLEC2B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLEC2B |
| Gene ID | 9976 |
| Uniprot ID | CLC2B_HUMAN |
| Accession Number | NP_005118 |
| Immunogen | Human |
| Immunogen Region | 26-149aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types. |
| Post Translational Modifications | (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. N-linked glycosylated.required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites. |
| Function | Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. |
| Protein Name | C-Type Lectin Domain Family 2 Member BActivation-Induced C-Type LectinC-Type Lectin Superfamily Member 2Ifn-Alpha-2b-Inducing-Related Protein 1 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneResting Nk Cells Contain Intracellular Stores Of Clec2b Associated With The Golgi Complex |
| Alternative Protein Names | C-Type Lectin Domain Family 2 Member B proteinActivation-Induced C-Type Lectin proteinC-Type Lectin Superfamily Member 2 proteinIfn-Alpha-2b-Inducing-Related Protein 1 proteinCLEC2B proteinAICL proteinCLECSF2 proteinIFNRG1 protein |
Information sourced from Uniprot.org