Human AICDA protein (Recombinant) (N-His) (STJP005971)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AICDA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AICDA |
| Gene ID | 57379 |
| Uniprot ID | AICDA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly23-Leu183 |
Additional Info
| Post Translational Modifications | Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126. |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
| Protein Name | Single-Stranded Dna Cytosine DeaminaseActivation-Induced Cytidine DeaminaseAidCytidine Aminohydrolase |
| Database Links | Reactome: R-HSA-9821002 |
| Cellular Localisation | NucleusCytoplasmCytosolPredominantly CytosolicIn The Presence Of Mcm3ap/GanpRelocalizes To The Nucleus |
| Alternative Protein Names | Single-Stranded Dna Cytosine Deaminase proteinActivation-Induced Cytidine Deaminase proteinAid proteinCytidine Aminohydrolase proteinAICDA proteinAID protein |
Information sourced from Uniprot.org