Human AICDA protein (Recombinant) (His-Tag) (STJP018002)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AICDA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AICDA |
| Gene ID | 57379 |
| Uniprot ID | AICDA_HUMAN |
| Accession Number | NP_065712.1 |
| Immunogen | Human |
| Immunogen Region | 1-198aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Strongly expressed in lymph nodes and tonsils. |
| Post Translational Modifications | Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126. |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
| Protein Name | Single-Stranded Dna Cytosine DeaminaseActivation-Induced Cytidine DeaminaseAidCytidine Aminohydrolase |
| Database Links | Reactome: R-HSA-9821002 |
| Cellular Localisation | NucleusCytoplasmCytosolPredominantly CytosolicIn The Presence Of Mcm3ap/GanpRelocalizes To The Nucleus |
| Alternative Protein Names | Single-Stranded Dna Cytosine Deaminase proteinActivation-Induced Cytidine Deaminase proteinAid proteinCytidine Aminohydrolase proteinAICDA proteinAID protein |
Information sourced from Uniprot.org