Human AgRP protein (Recombinant) (His-Tag) (STJP019105)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AgRP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGRP |
| Gene ID | 181 |
| Uniprot ID | AGRP_HUMAN |
| Accession Number | NP_001129 |
| Immunogen | Human |
| Immunogen Region | 21-132aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. |
| Protein Name | Agouti-Related Protein |
| Database Links | Reactome: R-HSA-9615017 |
| Cellular Localisation | SecretedGolgi Apparatus Lumen |
| Alternative Protein Names | Agouti-Related Protein proteinAGRP proteinAGRT proteinART protein |
Information sourced from Uniprot.org