| Function | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
| Protein Name | Af4/Fmr2 Family Member 4All1-Fused Gene From Chromosome 5q31 ProteinProtein Af-5q31Major Cdk9 Elongation Factor-Associated Protein |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-674695Reactome: R-HSA-75955 |
| Cellular Localisation | NucleusAssociates To Transcriptionally Active Chromatin But Not At Snrna Genes |
| Alternative Protein Names | Af4/Fmr2 Family Member 4 proteinAll1-Fused Gene From Chromosome 5q31 Protein proteinProtein Af-5q31 proteinMajor Cdk9 Elongation Factor-Associated Protein proteinAFF4 proteinAF5Q31 proteinMCEF proteinHSPC092 protein |
Information sourced from Uniprot.org
