Human AES protein (Recombinant) (His-Tag) (STJP017091)

Name: Human AES protein (Recombinant) (His-Tag) (STJP017091)
SKU: STJP017091
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017091

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Short Description	Recombinant-Human AES-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	TLE5
Gene ID	166
Uniprot ID	TLE5_HUMAN
Accession Number	NP_001121
Immunogen	Human
Immunogen Region	1-197aa
Immunogen Sequence	MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK NGHDGDTHQE DDGEKSD

Tissue Specificity	Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
Post Translational Modifications	Ubiquitinated by XIAP/BIRC4.
Function	Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Protein Name	Tle Family Member 5 Amino-Terminal Enhancer Of Split Amino Enhancer Of Split Gp130-Associated Protein Gam Grg-5 Groucho-Related Protein 5 Protein Esp1 Protein Grg Tle Family Member 5 - Transcriptional Modulator
Database Links	Reactome: R-HSA-4641265
Cellular Localisation	Nucleus
Alternative Protein Names	Tle Family Member 5 protein Amino-Terminal Enhancer Of Split protein Amino Enhancer Of Split protein Gp130-Associated Protein Gam protein Grg-5 protein Groucho-Related Protein 5 protein Protein Esp1 protein Protein Grg protein Tle Family Member 5 - Transcriptional Modulator protein TLE5 protein AES protein GRG protein GRG5 protein

Information sourced from Uniprot.org