Human ADRbK1 (Adrenergic Receptor Beta Kinase 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013344)

Human ADRbK1 (Adrenergic Receptor Beta Kinase 1) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013344)

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STJE0013344
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.105ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This ADRbK1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: GRK2
Gene ID: 156
Uniprot ID: ARBK1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Expressed in peripheral blood leukocytes.
Post Translational Modifications
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.
Protein Name Beta-Adrenergic Receptor Kinase 1
Beta-Ark-1
G-Protein Coupled Receptor Kinase 2
Database Links Reactome: R-HSA-111933
Reactome: R-HSA-416476
Reactome: R-HSA-418555
Reactome: R-HSA-5635838
Reactome: R-HSA-8856825
Cellular Localisation Cytoplasm
Cell Membrane
Postsynapse
Presynapse
Alternative ELISA Names Beta-Adrenergic Receptor Kinase 1 ELISA kit
Beta-Ark-1 ELISA kit
G-Protein Coupled Receptor Kinase 2 ELISA kit
GRK2 ELISA kit
ADRBK1 ELISA kit
BARK ELISA kit
BARK1 ELISA kit
output

Information sourced from Uniprot.org

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